Summary: High dimensional compositional and transcriptional Bedding profiling of heterogeneous brain-infiltrating leukocytes can lead to novel biological and therapeutic discoveries.High-quality single-cell leukocyte preparations are a prerequisite for optimal single cell profiling.Here, we describe a protocol for epitope and RNA-preserving dissoci
Clofazimine (CFZ) is a poorly soluble, weakly basic, small molecule antibiotic clinically used to ANTIPERSPIRANT ESCAPE treat leprosy and is now in clinical trials as a treatment for multidrug resistant tuberculosis and COVID-19.CFZ exhibits complex, context-dependent pharmacokinetics that are characterized by an increasing half-life in long term t
Immunotherapies are revolutionizing cancer care, producing durable responses and potentially cures in a subset of patients.However, response rates are low for most tumors, grade 3/4 toxicities are not uncommon, and our current Under Armour understanding of tumor immunobiology is incomplete.While hundreds of immunomodulatory proteins in the tumor mi
An improved multi-objective design optimization framework is proposed for the efficient design of proprotor blades tailored to specific high-altitude mission requirements.This framework Umbrella builds upon existing methods by leveraging a reformulated Vortex Particle Method (rVPM) and incorporates three key stages: (1) rapid determination of overa
SCF-type E3 ubiquitin ligases Under Armour provide specificity to numerous selective protein degradation events in plants, including those that enable survival under environmental stress.SCF complexes use F-box (FBX) proteins as interchangeable substrate adaptors to recruit protein targets for ubiquitylation.FBX proteins almost universally have str